Sunday, November 17, 2019

Specific neurons map location in the human brain

Illustration of parts of the brain - EPS VECTOR format also available in my portfolio.



The brain records our experiences in memory, enabling us to make fast decisions. Spatial cognition is represented by "place cells" and "grid cells" in the hippocampus and entorhinal cortex (located on the side of the brain). Individual neurons function as "memory-trace cells" that track spatial memory. Diseases like Alzheimer's disrupt the activity of location cells. Place cells and grid cells in the hippocampus and entorhinal cortex are among the first regions affected by the onset of Alzheimer's disease. These degradations lead to the observed memory deficits. 

Patients with implant electrodes in the brain can activate special "memory-trace cells" when they think of a particular place. Acting like a GPS, the neurons record and memorize the position in space. The activity of these neurons unmistakably identifies a location. A recent study has found that these memory-specific individual neurons function as a kind of GPS. Memory-trace cells in the entorhinal cortex encode memory representations through a memory-specific rate code. Single neurons change their spatial tuning to target relevant memories for retrieval.

Flexibility to change might improve our resilience to the disease.


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